Allan-Herndon-Dudley Syndrome (AHDS): An Overview

Abstract

Allan-Herndon-Dudley syndrome is major development disorders in brain. It causes intellectual infirmity and incoordination movement. This condition more common among in males, disturbs development from before birth. The Gene (SLC16A2) provides instruction for making a protein molecule that transports (T3) into nerve cells during development period. The individuals with Allan-Herndon-Dudley syndrome are unsteady while walking independently and become wheelchair-bound during adulthood. One study Stated AHDS in 1.4% of males with intellectual disability is due to unknown etiology. The causes are Mutation changes in MTC8 gene, followed by the clinical symptoms are ataxia, poor growth, dysarthria, hypotonia, muscle dystrophy, etc. The diagnostic evaluations are Genetic testing, antenatal diagnosis and genetic counselling. The Supportive Measures as follows. Physical, occupational, speech therapy may be beneficial. AHDS Children usually resembles normal at the time of birth and also have the signs of the disease, Progressive muscle weakness, hyperreflexia, joint deformities, stiffness and involuntary movements of the limbs that leads to wheel chair- bounded during adulthood. Some children also reported with delayed language development.