Covid Vaccination in Pregnancy: An Overview

Abstract

Pregnancy is associated with a higher incidence of severe Covid-19. It is crucial to find vaccinations that trigger protective immune responses in pregnant women and fetuses. An analysis of epidemiological studies evaluating mRNA vaccines summarizes Infection rates, maternal antibodies, placental antibody transmission, and adverse events after pregnancy vaccination against COVID-19. Using mRNA-based vaccines, pregnant women can be protected from COVID-19 infection. The COVID-19 vaccination had no effect on pregnancy, childbirth, or perinatal mortality. Among the most common side effects are pain at the injection site, fatigue, and migraines. Pain at the injection site, fatigue, and migraines are the most common side effects. Additionally, adaptive immunity is associated with improved placental antigen transmission after booster vaccination. A two-dose vaccination is associated with higher maternal and fetal antibody levels. There is evidence that longer delays between the first immunization dosage and birth are associated with higher levels of fetal IgG antibodies and lower levels of antigen transmission. It has been shown that mRNA vaccines reduce the severity of COVID-19 infection, and these vaccinations are considered safe for pregnant women and their unborn children.