Journal of Advances in Bio- pharmaceutics and Pharmacovigilance
http://matjournals.co.in/index.php/JABP
<p><strong>JABPP</strong> publish quality case reports, original research and review articles about the pharmaceutical intervention safety, side effects and adverse effects as well as medications toxicity. The journal with a wide scope in the arena of pharmaceutical sciences covers the topics intended to be of interest to a broad audience of pharmaceutical professionals and ideally placed to serve the needs of their readers. The focus of this Journal includes Clinical Research, Pharmacovigilance, USDFA/EU, Market Research, Pharmacovigilance Compliance and Management, Signal Detection, Pharmacovigilance Regulations and Guidelines.</p>en-USJournal of Advances in Bio- pharmaceutics and PharmacovigilanceInsights into Recent Advancements in Pharmacotherapeutics for Allergic Conjunctivitis
http://matjournals.co.in/index.php/JABP/article/view/4367
<p><strong>As much as 40 percent of the population in the first world suffers from allergies, making it the sixth most common chronic condition overall. Its pathogenesis is influenced by the immune system's sensitization to antigens and environmental stimuli and includes a hereditary component. Novel treatment development for ocular allergies should advance when the mediators responsible for the condition are identified via ongoing study. PubMed and Medline were used to conduct a literature review on allergic conjunctivitis, ocular allergy, and their respective treatments. Information from clinicaltrials.gov and other related websites on medications now in clinical trials is also provided. Identifying and avoiding allergen triggers is always the first step in treatment. The latest generation of dual-acting antihistamines is the backbone of therapy. The introduction of drugs that provide greater and longer-lasting comfort to a higher percentage of subjects is a slow but steady process. The availability of models like the conjunctival allergen challenge makes allergic conjunctivitis an accessible condition to investigate. Through the use of these models, we are getting closer to discovering the next generation of anti-allergic treatment by testing compounds that inhibit inflammatory pathways or mediators involved in the onset and resolution of an allergic reaction.</strong></p>Leena YadavDivya RathoreAarti Chandra
Copyright (c) 2023 Journal of Advances in Bio- pharmaceutics and Pharmacovigilance
2023-10-132023-10-13824Deep Insights into Advances in Polyelectrolyte Complex Formulations
http://matjournals.co.in/index.php/JABP/article/view/4655
<p><strong>Over the past few years, there have been notable advancements in the field of novel drug delivery techniques. The creation of polyelectrolyte complexes and the phenomenon of interpolymer interactions have been the subject of much basic and applied study. New physicochemical properties and high biocompatibility distinguish interpolyelectrolyte compounds. Polymers of all kinds and combinations have been investigated. Recent years have seen a rise in interest in polyelectrolyte complexes as researchers discover new uses for them. Their ability to incorporate charged species makes them useful as carrier systems for medicines, enzymes, and DNA. These have a wide variety of potential applications, including membranes for NPs for targeted tissue delivery, medical applications, organelle trafficking and imaging, enzyme mimics, biosensor development, contact lenses, enzyme immobilization, dialysis, and hydrogels for tissue engineering. In such amalgamations, properties that are not shared by the individual pieces may surface. We concentrate on the potential applications of polyelectrolyte complexes in drug delivery in this research.</strong></p>Tanvi Tushar SambreTushar Kishore SambreBharti Sahu
Copyright (c) 2023 Journal of Advances in Bio- pharmaceutics and Pharmacovigilance
2023-12-162023-12-165058Drug Use Pattern in Hypertension Condition
http://matjournals.co.in/index.php/JABP/article/view/4411
<p>Hypertension, commonly known as high blood pressure, is a prevalent chronic condition affecting a substantial portion of the global population. Effective management of hypertension is crucial in mitigating the risk of cardiovascular complications. Pharmacological intervention serves as a cornerstone of treatment, and this study aims to analyze the contemporary drug use pattern in hypertension management. A range of antihypertensive drug classes, including angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), calcium channel blockers (CCBs), diuretics, and beta-blockers, are widely utilized as first-line agents in the management of hypertension. These drugs act through various mechanisms, such as reducing peripheral resistance, modulating fluid balance, and affecting cardiac output, ultimately leading to the reduction of blood pressure. However, the choice of the specific class of antihypertensive drugs depends on individual patient characteristics, including age, comorbidities, and potential contraindications. Clinical evidence has demonstrated that monotherapy might not always achieve adequate blood pressure control, necessitating the use of combination therapy to attain target blood pressure levels. Although combination therapy has proven effective, concerns about polypharmacy-related complications and adverse drug interactions have been raised, highlighting the importance of regular monitoring and careful management. Non-adherence to prescribed antihypertensive regimens poses a significant challenge in hypertension management. Patients often struggle with complex dosing schedules, pill burden, and adverse effects, leading to suboptimal control of blood pressure and increased cardiovascular risks. Strategies addressing patient education, simplification of drug regimens, and the use of long-acting formulations have been proposed to improve medication adherence and overall treatment outcomes. Recent advancements in hypertension management have introduced novel therapeutic options, such as mineralocorticoid receptor antagonists and vasodilators, providing additional choices for patients with resistant hypertension or specific comorbidities. These developments underscore the need for individualized treatment plans tailored to the unique requirements and responses of each patient.</p>S. Prathamesh IthapeM AvezBharat DhoreRamesh R Pagore
Copyright (c) 2023 Journal of Advances in Bio- pharmaceutics and Pharmacovigilance
2023-10-272023-10-272529Exploring the Natural Bliss: A Comprehensive Review of Natural Lip Balms
http://matjournals.co.in/index.php/JABP/article/view/4060
<p>Throughout history, the allure of cosmetics has remained strong, and in modern times, there is a growing preference for products crafted from natural ingredients. Among these, lip balms hold a special place as they accentuate the beauty of lips and add a touch of glamour to makeup. Moreover, lip balms offer a natural way to maintain and nourish healthy lips. Unfortunately, many contemporary cosmetic lip products heavily rely on potent chemicals, leading to various undesirable effects. To address this concern, the present work focuses on researching the utilization of natural components in the creation of lip balms. This article delves into the key ingredients employed in natural lip balm formulations, exploring their advantages and disadvantages. Natural lip balms can be formulated using various elements, including foundations, oils, extracts, colorings, and flavorings, all derived from natural sources. The use of these components aims to provide users with a safer and more sustainable alternative to conventional lip products. By opting for natural lip balms, individuals can avoid the potential harm caused by harsh chemicals and instead experience the benefits of organic, plant-based ingredients. This investigation sheds light on the potential of natural lip balms, emphasizing the importance of embracing nature's gifts for personal care. As consumers become increasingly mindful of the impact of their choices on both their well-being and the environment, the demand for natural lip balm continues to surge. By understanding the properties and effects of these natural elements, individuals can make informed decisions about the lip balms they use, fostering a healthier and more eco-conscious approach to lip care and beauty.</p>Shedge Vaishnavi S.
Copyright (c) 2023 Journal of Advances in Bio- pharmaceutics and Pharmacovigilance
2023-08-082023-08-0817Assessment of Potential Adverse Drug Reactions Associated with Cardiovascular Medicines
http://matjournals.co.in/index.php/JABP/article/view/4536
<p><strong>Background: Every drug has the potential to cause ADRs. Cardiovascular medications are a major problem in drug therapy as they can result in several consequences, ranging from allergic reactions to permanent harm. We have undertaken a meta-analytic review of various types of studies performed in different hospital settings to understand the importance of ADRs in CVD patients and how ADRs might be better detected, evaluated, and avoided.</strong></p> <p><strong>Objectives: To study various factors and assess the incidence, causality, severity, and preventability of ADRs associated with cardiovascular drugs.</strong></p> <p><strong>Methods: Meta-analytic study conducted over 6 months by reviewing 24 articles finalized from 58 articles collected from various data sources like Clin Med, Pubmed, and Medline. Information related to ADRs was analyzed by using demographic data through various questionnaires and scales in articles. </strong></p> <p><strong>Results: A total of </strong><strong>4421 ADRs were reported among 9759</strong><strong> patients. 8/24 of the studies performed causality assessment by using the Naranjo scale and 12/24 used the WHO-UMC scale. 9/24 studies assessed severity and 5/24 studies performed preventability assessments. The incidence of ADRs was high in the 40-80 age range (</strong><strong>94.69%).</strong><strong> Commonly prescribed drugs were </strong><strong>calcium-channel blockers and beta-blockers in CVD patients</strong><strong>.</strong><strong> Organ systems like the cardiovascular, central nervous and respiratory systems were commonly affected. Most ADRs were mild and possible. Females experienced more ADRs compared to males.</strong></p> <p><strong>Conclusion: Although this study provides estimates of the incidence, severity, and preventability of ADRs in different settings, further studies are needed for monitoring ADRs in patients using CVD drugs to address how such ADRs will be prevented.</strong></p>Nikhitha AlugubellyLokesh BayyapuKeerthi Priya AregudemJashwanthini Challapally
Copyright (c) 2023 Journal of Advances in Bio- pharmaceutics and Pharmacovigilance
2023-11-292023-11-293049