GABA from Medical Nutrition to Pancreatic Beta-Cell Regeneration

Abstract

Introduction: Type 1 diabetes is considered as one of the most widespread chronic diseases in the world, which happens due to autoimmune damage of beta cells in islets of langerhans in the pancreas. It is the most widespread type of diabetes in young age below 18 years. The beginning or progress of autoimmune cellular injury of pancreatic beta cells could occur through the presence of many autoantiges which are detected in the pancreatic beta cells. It was found that GABA promoting proliferation of beta cells which may have good impact on type 1diabetes. Design: Randomised, placebo controlled trial, 6 month trial. Materials and Methods: 100 type 1 diabetes patients were randomized into 2 groups. Result: The results show a statistically significant decrease of antigad antibodies and an increase of c peptide levels after 6 months of treatment with GABA. Conclusion: GABA may be used for decreasing antigad antibodies and beta-cell regeneration.