Journal of Molecular Pharmaceuticals and Regulatory Affairs http://matjournals.co.in/index.php/JMPRA <p><strong>JMPRA</strong> is a unique journal dedicated to scientists and pharmaceutics to publishing the articles. This Journal provides platform to Researchers, Academicians, Scholars, and Professionals in the Pharmacy domain to promulgate their Research/ Review/ Case studies in the field of Molecular Pharmacy. The areas covers up in this journal are Molecular basis of Disease, Molecular Pharmaceutics, Medical Diagnostics, Molecular therapy, Molecular Medicine.</p> en-US Tue, 11 Oct 2022 05:58:50 +0530 OJS 3.3.0.8 http://blogs.law.harvard.edu/tech/rss 60 The Process and Metabolism of Chemical Carcinogenesis http://matjournals.co.in/index.php/JMPRA/article/view/1118 <p>The potential for DNA damage and the activation of specific oncogenic pathways that cause inflammation are present in a wide range of physical, chemical, and biological variables that are constantly present in human beings. According to certain theories, chemical carcinogens are the primary etiological factor in cancer. These substances interact either or non-covalently with the DNA, RNA, and proteins in human tissue, which helps to initiate carcinogenesis, a process in which genetic mutation and changes to the transcription of the genome take precedence. These carcinogens act as cancer cell growth initiators or promoters. When DNA, RNA, or proteins are alkylated, covalent connections are first formed with them and then the promoting action occurs. The process involves numerous molecular and cellular changes that turn normal cells into plastic cells. Although it is hypothesized that these endogenous chemical processes could cause DNA damage by inducing gene changes with the aid of reactive oxygen species. This review's focus is on the basic mechanism and metabolism of chemical carcinogenesis. Chemical carcinogens are supposedly considered to be the key etiological factor of malignancy. The covalent or non-covalent bonds between these chemical and the DNA, RNA, and proteins of human tissue help in the initiation of carcinogenesis wherein, genetic mutation and alteration in the genome transcription supervenes. These carcinogens behave as initiators or promoters of cancer cell growth. Alkylation of DNA, RNA, or proteins and the formation of covalent bonds with them begin initially followed by the promoting effect. Numerous molecular and cellular events causing the transformation of normal cells into neoplastic cells occur in the process. It is assumed though those endogenous molecular pathways could instigate mutations in respective genes with the support of reactive oxygen species, thus leading to DNA damage. Thus, this review deals with the basic mechanism and metabolism of chemical carcinogenesis.</p> Priyanka Pandey, Wasim Raja Copyright (c) 2022 Journal of Molecular Pharmaceuticals and Regulatory Affairs http://matjournals.co.in/index.php/JMPRA/article/view/1118 Tue, 11 Oct 2022 00:00:00 +0530 The Effects of Alchornea laxiflora Leaf Extract on Total- and HDL- Cholesterol Levels in Serum, Liver, and Kidney of Rats http://matjournals.co.in/index.php/JMPRA/article/view/1237 <p>Alchornea laxiflora is one of the underutilized tropical plants in Nigeria. The extract from the leaf has been shown to contain certain phytochemical principles which have been linked to some of its medicinal uses.</p> <p>The effect of<em> Alchornea laxiflora</em> aqueous leaf extract on the level of the total- and high-density lipoprotein (HDL) - cholesterols in the serum, liver, and kidney of rats was evaluated in this study. Twelve rats were grouped into three containing four each. Group A (control) was administered with only distilled water. Groups B and C were administered with aqueous extract of <em>Alchornea laxiflora</em> at 100 mg kg<sup>-1</sup> and 200 mgkg<sup>-1</sup> body weight respectively for twenty-eight days. The result revealed a decrease in the level of total cholesterol in the serum and kidney of rats administered with aqueous leaf extract of <em>Alchornea laxiflora</em>. It can therefore be suggested that <em>Alchornea laxiflora</em> holds much promise in offering protection against possible lipid peroxidation and lowering the level of total cholesterol in the serum and kidneys of rats.</p> Ogunbiyi O. J., Apata J. T., Jegede R. J., Akinola F. T. Copyright (c) 2022 Journal of Molecular Pharmaceuticals and Regulatory Affairs http://matjournals.co.in/index.php/JMPRA/article/view/1237 Mon, 14 Nov 2022 00:00:00 +0530 Development in Novel Drug Delivery Systems http://matjournals.co.in/index.php/JMPRA/article/view/1240 <p>Plants are used by human beings since earlier times for medicine and food. There are some research are carried out to find a suitable treatment for mankind through new drug delivery systems. However herbal medicaments also require modification for sustained release. By using modern methods protection from toxicity, improved stability, and bioavailability of herbal preparations, this review gives information about new techniques used for better safety and efficacy.</p> <p>Recently the advanced in the understanding of pharmacokinetics and pharmacodyanmic behaviour of drug have of offer a more rational approach to the development of optimal drug delivery system. Now it’s appreciable that future success in drug delivery research will largely be result of multidisciplinary efforts. If any therapeutic agent that can be efficacious and safe using and improved drug delivery system represent both lucrative marketing opportunities for pharmaceutical company and advancement in the treatment of disease of mankind. An ideally designed drug delivery system delivers a specified amount of drug to targeted particular site at an appropriate time and rate as dictated desired by the etiological and physiological needs of body.</p> <p>&nbsp;</p> <p>Conventional pharmaceutical dosage form is incapable of controlling the rate of drug delivery to targeted site. As a result the distribution of drug in non-targeted tissue and body fluids necessitate therapeutic dosage that could exceed the amount required in targeted cell.</p> <p>The novel drug delivery system is carriers which maintain the drug concentration in therapeutic range for longer period of time and also in addition may deliver the content to the site of action if so desired as per requirements.</p> Vaibhav P. Khupase, Prajwal A.Gholap, M. Avez, M. Ayaz, R.R.Pagore, B. B. Dhore Copyright (c) 2022 Journal of Molecular Pharmaceuticals and Regulatory Affairs http://matjournals.co.in/index.php/JMPRA/article/view/1240 Mon, 14 Nov 2022 00:00:00 +0530