Formulation and Evaluation of Luliconazole Suppositories for the Treatment of Candida Infection (vulvovaginal candidiasis)

Abstract

Vaginal infection is one of the most prevalent gynecologic issues. Each obstetrician-gynecologist receives about 500 visits as a result of these illnesses every year; this represents more than 7% of all patient visits to these doctors. Yeast infection is one of the most often occurring causes of inflammation in the vaginal region and on the female genitals' outer skin. Itching, a burning sensation, and pain are symptoms of a vaginal yeast infection. Human genitalia frequently contain a form of yeast called candida albicans. An opportunistic infection called candidiasis is brought on by the fungus candida. Luliconazole, an imidazole antifungal drug, inhibits the growth of the candida albicans fungus. The purpose of the current study was to formulate and describe luliconazole vaginal suppositories for the treatment of vulvovaginal candidiasis. Using a typical 1g moulds and the fusion procedure, luliconazole suppositories were created using various glycerin, gelatin, and carbopole base compositions. Physical characteristics, homogeneity of weight, disintegration time, drug content, in vitro dissolving study, and in vitro stability studies of the suppositories were all assessed. All of the formulations (F1-F10) examined demonstrated equal levels of drug release and dissolution, with F1 demonstrating the highest levels of dissolution (98.52 percent in 1 hour) having a 16.4 minute disintegration time and a 97.2 0.55 hour drug release. Even from the results of stability experiments, it can be inferred that F1 exhibited the least amount of change in drug content hardness, melting point range, or drug release while kept in various storage environments, including those with varying humidity levels, direct sunlight, and room temperature. Even four weeks into the time frame. The F10 Suppositories demonstrated the least amount of drug release, or 91.450.15 percent in 6 hours with a disintegration time of 26.26, and their highest amount of drug release, being 89.32 in 1 hour. The inclusion of higher molecular weight gelatin and carbopol, which has a poor solubility in aqueous medium, makes for a slower drug release. The best formulation for delivering the medication is suggested to be F1.