Synthesis, Characterization of various Imidazole-1,3,4-Oxadiazole Derivative

Abstract

The heterocyclic system (such as imidazole, Oxadiazole) and their derivatives have attracted so much attention due to their valuable properties. Imidazole, Oxadiazole compound have caught so much attention due to their vital used in various fields or disease. Imidazole can be used as anti-fungal, antiprotozoal, antihypertensive, Oxadiazole can be used as antitussive, anti-inflammatory, anesthetic, vasodilator, anthelmintic, antiallergic and antiplatelet. The syntheses of these five derivatives were carried out. In first step Ethyl 2-(1H-imidazol-1-yl) acetate is prepared, this Ethyl 2-(1H-imidazol-1-yl) acetate is used to prepare 2–(1H–imidazol-1–yl) acet–hydrazide. Afterward in this benzaldehyde (i.e. 4-hydroxybenzaldehyde, 3-hydroxybenzaldehyde, 3-nitrobenzaldehyde, 4-aminobenzadehyde, 3-methoxybenzaldehyde) is added, in next step by adding acetic anhydride the desired derivatives were formed. ATR-FTIR studies were carried out in which the groups present in of compound were determined such as such as C-H group, C-O group, C-O-C group, N-C group, C=O group, O-H group. 1H-NMR studies were also performed. The structures of different derivatives were determined by 1H-NMR. According to the nature or number of hydrogen present on the neighboring atom the splitting of peaks occurs.