Developing and Characterizing Novel Medicated Ointment Formulations containing Therapeutically Active Extracts of Artemisia dracunculus and Corynanthe yohimbe for Skin Applications
Keywords:
Artemisia dracunculus, Characterization, Coryanthe yohimbe, Extract, Formulation, OintmentAbstract
The goal of the current study was to investigate potential applications for extracts of Artemisia dracunculus (leaves) and Corynanthe yohimbe (bark) used in ointment formulations. The pharmaceutical properties of the formulations, such as pH, the skin irritancy test, viscosity, appearance, extrudability, spreadability, washability, and swelling index, were evaluated. The skin irritation test inquiry found that no particular edema or erythema symptoms appeared after therapy for a continuous seven days. pH measurements of the formulations were 6.1 (F1) and 6.5. (F2). While F2 showed edema of 1.16%, F1 showed swelling of 1.31%. The two ointment compositions' respective spreadabilities were “6.8 g.cm/sec and 6.3 g.cm/sec”. The formulae for F1 and F2 were found to be +++ and +++, respectively, extrudable from the collapsible tubes. “In light of the formulations' rheological characteristics, the viscosity was found to be 4600 cps (F1) and 5500 cps (F2)”. “The washability of the formulations was found to be +++ for Formulation-1 and +++ for Formulation-2”. By making this finding, which also revived the ideas of Ethnopharmacology in connection to modern medicine, the uses of polyherbal formulations in conventional medicine were made clear.