Influence of Brassica oleracea on Vitamin D3 level in Albino Rats with Oxidative Stress

Abstract

Medicinal plants are important to human life for their role in detoxification and are associated with no or reduced side effects, several medicinal plants have shown a protective effect for the liver and kidneys in liver and kidney disorders caused by paracetamol, gentamicin, profenofous, chronic stress, toxic drugs, nephropathy, diabetes and chemical media-induced nephrolithiasis. Broccoli is Brassica olerace var. Italica is one of the types of medicinal plants found in the Mediterranean region, and it is an annual herbaceous plant similar to cauliflower in external appearance, as it is characterized by its high nutritional value, and it is considered one of the foods free of fat, sodium and calories, and it is also a good source of many vitamins such as vitamin A and D And C, niacin, riboflavin, carotenoids and folic acid, and it also has good therapeutic properties, as it is a strong regulator and antibiotic for many common diseases, as it reduces high blood pressure and helps lower cholesterol level in the blood, regulate sugar level, increase physical strength and build bones, and it also helps It protects against heart disease, venereal and urinary diseases and reduces the incidence of cancer, and is also a rich source of anti-cancer glucosinolates (Gls), and it has been proven that eating more than one meal during the week reduces the risk of cancer by 45%, and it also helps prevent retinal diseases. Paracetamol or acetaminophen is widely used because of its analgesic and antipyretic properties in many cases that do not require a prescription in both adults and children, and it is taken orally to relieve pain in mild, medium and severe cases, and intravenous administration has become widespread. Also, the recommended therapeutic dose of paracetamol is 4 g/day for adults and 50-75 mg/kg/day for children, but doses of more than 7 g in adults and 150 mg/kg in children are toxic to the liver and kidneys due to the toxic metabolite. (NAPQI) Highly active N-acetyl-para-aminophenol formed by the oxidation of paracetamol via the cytochrome pathway. Paracetamol overdose is one of the most common drug-related toxicities reported to poison centers, and is the leading cause of acute liver failure in the United States. To reduce the risk of hepatotoxicity, the Food and Drug Administration requires manufacturers to include a black box on all formulations containing the drug warning of potential liver damage.