Adams Oliver Syndrome

Abstract

Adams–Oliver syndrome (AOS) is characterized by various malformations of the limbs and abnormal skin development, particularly over the scalp. Adams-Oliver syndrome is a rare condition. The prevalence is unknown. It is considered to be very rare, with an incidence rate of 1/225,000 live births. AOS is caused due to genetic mutations of 6 genes. The primary features are Aplasia cutis congenital, Cutis marmorata telangiectatica congenital and Other features are cardiac defects, pulmonary hypertension, and developmental disability. AOS is diagnosed based on clinical features, patient/family history, and imaging. The treatment modalities are Skin grafting, Physical therapy, surgery and use of prostheses for limb malformations.