Trends in Pharmaceuticals and Nanotechnology (e-ISSN: 2582-4457)

Formulation and Evaluation of Colon Targeted Ciprofloxacin Microspheres

Ch. Srilatha — Sat, 30 Sep 2023 00:00:00 +0530

In the present study, Colon-targeted Ciprofloxacin hydrochloride microspheres were formulated and their in vitro properties were assessed to determine whether or not the antibiotic could be delivered to the colon. By utilizing span-80 as an emulsifying agent, ciprofloxacin hydrochloride microspheres for colon targeting were prepared using the emulsion-solvent evaporation method. According to the preliminary trial findings, the ratio of drug to polymer had an impact on the microspheres' properties. The Ciprofloxacin: Eudragit S-100+HPMC 6cps ratio of 1:1, 1:2, 1:3, 1:4, 1:5, and 1:6 were used to make the colon targeting microspheres, in which the ratio of Eudragit S-100 to HPMC was always 1:1. The combination of Eudragit S-100 and HPMC demonstrated increased release lag time and regulated release rate, which improved protection of the drug-containing core. For the majority of the formulations examined, zero-order release followed a time delay caused by the hydrogel's swelling/retarding behaviour before the medication started to come out of the microspheres. The colon-targeting microspheres were also tested for micrometrics, particle size and surface properties, percentage drug content, encapsulation effectiveness, and in vitro drug release study in the three different pH environments (0.1 N HCL, Phosphate buffer pH 6.8 and Phosphate buffer pH 7.4) for 12 hours. The kinetics of drug release in vitro and the drug release mechanism of the microspheres were further investigated. With a particle size of 58.9 m, an almost spherical shape, and free-flowing characteristics, the best formulation batch had the highest drug entrapment efficiency of 86.81%. It was followed by a zero-order rate release with a non-fiction-diffusion mechanism, which had an 82.77% drug release rate.

Polymeric and Ceramic Nanoparticles as Nutraceuticals in Polyherbal Formulations

Nabamita Sen, Narasimha Buragommula, Hephzibha B, P. Veeresh Babu — Sat, 03 Jun 2023 00:00:00 +0530

Currently, a wide range of diseases are treated using a variety of nutraceuticals. For quick action at the target location, many kinds of nanoparticles are utilised in targeted drug delivery systems. The current article covered many natural nutraceuticals that have been proven to be more effective when combined with pharmaceuticals. Nanoparticles made of polymers and ceramics are essential to the innovative medication delivery method. This page explored several forms of nanoparticles, offering a wealth of information on the subject of nanotechnology. Because of their improved bioavailability, nutraceuticals have a huge impact on the treatment of many different ailments without causing any negative side effects. Marketed nanoparticles include nano gels, nanocapsules, nanospheres and dendrimers. In the current article the list of marketed products and its uses in treating various disorders are enlisted. Various natural drugs are available in nature, which can be useful in many aspescts when used in combination with nanoparticles. Innovative work in the field of science and technology proved to be beneficial in upcoming generation for a mankind. Various targeted drug delivery system also proved beneficial with nutraceuticals in treating cancerous cells and better therapeutic action. Nanoparticles in different types are available for the fast action of drugs to the target site, so in combination with nutraceuticals showed widespread effect in medical field. In the research field many new inventions are updated to serve humanity and if nutraceuticals are also used as a treasure with combination of Nano science it will be more effective and fruitful for the nation.

3D-Printed Composites: Multiple Applications, Recent Advances, and Emerging Prospects

Vivek Kahale, Madhukar Shende — Sat, 30 Sep 2023 00:00:00 +0530

3D printing technology (3DPT) is presently extensively employed in several areas of R&D. Unfortunately; the practical potential of this potentially revolutionary technology is now constrained by the narrow spectrum of physicochemical properties available in 3D-printed materials. High-performance composites made from many materials, each with its unique features, are becoming more popular as a means to improve and vary the characteristics of standard printing materials. In the past, 3D-printed composites have been employed for a wide range of purposes, including the creation of biological, mechanical, electrical, thermal, and optical enhancements. Rapid prototyping has increased the popularity of 3DP composites because of their ability to create complex geometries at a cheap cost. This study reveals that traditional 3DP materials may be upgraded to produce composites with enhanced biometric, electrical, mechanical, optical, thermal, and other characteristics by using nanoparticles, fibres, other polymers, or a chemical reaction.

Global Contributions on Nanotechnology of Regulatory Aspects of Drugs

Sai Grandhi Meena, Koushik Yetukuri — Thu, 24 Aug 2023 00:00:00 +0530

Background and Objective: The food, pharmaceutical, and agricultural industries can contribute to, develop, and benefit from the use of nanotechnology, which is a major advanced technology. The manufacture of healthier, safer, and high-quality functional foods that are perishable or semi-perishable could be led qualitatively and quantitatively by nonmaterial. Nanotechnology has become one of the most significant frontline areas in many traditional study areas of science and technology.

Methods: It contains several international regulations that have helped spread awareness of the value of nanotechnology in pharmaceuticals. The article on pharmaceuticals and food was framed following the regulatory authorities of each country's criteria.

Results: Nanotechnology's uses in emerging nations' products, including medicine, and other goods.

Conclusion: The potential for nanotechnology to advance food research across a wide range of disciplines is considerable. These nanomaterial devices have numerous uses in the food industry, including food processing, preservation, and packaging. Different nanomaterials have been used for a variety of biomedical applications, including drug delivery systems, optical imaging, and bioimaging, depending on the physical and chemical properties of their surfaces. For the benefit of all people, it justifies paying attention to the incredibly promising topic of nanotechnology.

Recent Perspectives of Nanotechnology in Pharmacotherapeutic Potential against Emerging Diabetes Mellitus

Vivek Kahale, Madhukar Shende — Sat, 16 Dec 2023 00:00:00 +0530

Many different therapy techniques are used to treat type 2 diabetes mellitus (T2DM). When diet and exercise are insufficient to manage hyperglycemia, patients are forced to start using antidiabetic drugs. However, these drugs' adverse effects may alter how a patient is managed. The main disadvantages of the current oral treatment regimens for type 2 diabetes are mostly related to the drug's rapid release and low absorption, which require increasing the frequency of doses. When adverse side effects start to manifest, patient compliance with therapy declines. Recent advances in nanotechnology have made it possible to create novel delivery methods that might increase the efficacy of diabetes treatment plans. The two crucial processes that have been the focus of all the effort are (a) encasing the medication in a nano-carrier system to preserve it, and (b) releasing the drug in a controlled and gradual manner. However, very few studies that were published in the literature used in vivo techniques to support their findings. Here, we review the limitations of currently available T2DM drugs and discuss recent developments in nanotechnology supported by in vivo glucose homeostasis models in mice and rats. The creation of medicinal nanocarriers that have longer release times, lower dosages, and more bioavailability might improve patient compliance. This creative solution might greatly enhance the quality of life for diabetics. Also explored is the use of metal nanoformulations as indirect hypoglycemic agents.