Pharmaceutical Aspects of Self Emulsifying Drug Delivery System: A Comprehensive Review

Abstract

Low aqueous solubility of the newly discovered drug possesses a great challenge for the development of dosage form with suitable applicability. Self-Emulsifying Drug Delivery System (SEDDS) provides an excellent alternative for increasing solubility of lipid soluble drugs which is achieved by microemulsion through chemical means. Self-Emulsifying drug delivery system is the blend of surfactants and oils which are isotropic in nature. It also includes co-solvents which upon gentle agitation gets emulsified under conditions mimicking to those which would be encountered in the gastrointestinal tract. This article discusses mechanism components, pharmaceutical aspects, patents and recent work done on SEDDS.