Cushing Syndrome: A Review and Its Treatment by Emerging Molecule Osilodrostat

Abstract

Cushing syndrome is mainly the Hypercortisolism state in our body which is due to many factors like inappropriate exposure of Glucocorticoids. It can be endogenous as well as exogenous depending upon the cause and responsible factors. Screening of Cushing syndrome includes procedures like UFC test, Low Dose DST, Low dose salivary cortisol levels. Diagnosis of the Syndrome involves the MRI of Pituitary gland, Overnight Dexamethasone test. Some of complications arising from this syndrome are excessive weight gain, Hypertension, Diabetes mellitus, decreased immune response, depression and Depression. Treatment of Cushing syndrome is done by various therapies like Pituitary surgery, adrenal surgery and medical treatment which involve use of various drugs for treatment. Osilodrostat has shown very impressive results in treatment of Cushing Syndrome as compared to other available options of drugs like Ketoconazole and Metyrapone. Further studies are to be done on Osilodrostat to conclude a perfect and permanent treatment of Cushing Syndrome.