A Review on Correlation of Obesity and Alzheimer- Perspective Study

https://doi.org/10.46610/RTPScR.2023.v05i02.002

Abstract

Due to excessive consumption of saturated fats, inactivity, or a sedentary lifestyle, obesity is a widespread health issue that is getting worse around the world. Alzheimer's disease (AD) is caused due to breakdown of amyloid precursor protein to secretase; aggregation and hyperphosphorylation of tau are additional causes that result in NTFs. Over the past couple of decades, cases of dementia, or in more advanced terms, Alzheimer's, have elevated in middle-aged individuals and primarily in the elderly population. We go through the relationship between obesity as well as the pathology of AD in this review. Key elements that are thought to contribute to the development of obesity-induced AD are extensively examined. The impact of a high-calorie food on the brain, the function of insulin, processes through which insulin resistance develops are all examined. Leptin's function in the brain and its resistance, as well as molecular factors including mitochondrial dysfunction, the production of inflammasomes, and the roles of peripheral and central tenderness in the development of obesity-induced AD, are all examined. However, some believe that to be a contentious issue and to determine the specific situation, more investigation is required.