Antimalarial Drugs Special References with Their Sub Classification Based on Quinoline

Abstract

From 1990 to the present, the patent and main scientific literature relevant to research on quinoline antimalarial drugs is reviewed. This includes 4-and 8-aminoquinolines, quinolines methanol and a variety of other chemicals. A brief historical overview of the key quinoline medications and a summary of current knowledge of their mode of action and mechanisms of resistance. Chloroquine and primaquine replacement and supplementation candidates are discussed. People's health and current economy on a global scale are significantly threatened by the severe acute respiratory syndrome coronavirus (COVID-19) outbreak. Due to the COVID-19, most countries throughout the world are currently conducting substantial research to better understand the antimalarial chloroquine (CQ) and hydroxychloroquine (HCQ) for medicinal purposes outbreak. CQ and HCQ, on the other hand, can have major adverse effects, ranging from psychological disorders to abrupt death. To monitor drug concentrations, a faster and more effective detection approach is required. A large investigation of detection techniques and quantitative analysis was undertaken in this review. CQ and its associated metabolites determination techniques Chromatography, electrophoresis, electroanalytical, spectroscopic and immunological techniques for CQ and associated metabolites are covered in depth in this review. It's true and believed that a better understanding of the CQ would lead to a better comprehension of the COVID-19 epidemic, and therapeutic purposes will be supplied.